The consumption of PGX® in concert with lifestyle modifications may be a useful strategy for weight loss in overweight and obese individuals.Read Less…
Viscous soluble dietary fibre has been demonstrated to reduce postprandial glycaemia and may promote satiety. PolyGlycopleX® (PGX®) is a highly viscous polysaccharide manufactured by reacting glucomannan with other soluble polysaccharides using a proprietary process (EnviroSimplex®). The resulting polysaccharide PGX (a-D-glucurono-a-D-manno-b-D-manno-b-D-glucan),(a-L-gulurono-b-D-mannuronan),b-D-gluco-b-D-mannan (a-D-glucurono-a-D-manno-b-D-manno-b-D gluco),(a-L-gulurono-b-D-mannurono),(b-D-gluco-b-D-mannan ) is a novel entity with the highest viscosity and water-holding capacity of currently known fibres.
Materials and Method:
A total of 29 sedentary overweight or obese adults (23 women; six men), ages 20-65 with a body mass index (BMI) range of 25 kg/m2 to 36 kg/m2 participated in a clinical weight-loss program. PGX (5 g) was consumed with 500 mL water, 5-10 minutes before each meal, 2-3 times daily for 14 weeks.
Significant reductions were observed (p<0.05) in weight (-5.79 ± 3.55 kg), waist circumference (-12.07 ± 5.56 cm), and percentage body fat (-2.43 ± 2.39%) compared to baseline values. In addition, subjects employing PGX had a significant reduction of 19.26 percent (n=17; p<0.05) and 25.51 percent (n=16; p<0.05) in total and LDL plasma cholesterol values, respectively, at the end of the study period.